The HPLC analysis ofthe last samples colleceted in the permeation assays allowed to
caleulate the percentage ofbioactive compounds that permeated through the biologieal
barrier after 24 hours as well as their permeation fluxes, expressed as hg em? hi (Table
3). Asp-eoumarie acid and caffeic acid are slightly lipophilic, iis possible that, even 放
they did not manage to pass the s/rgjo corjezo, they were trapped in the human
membrane, happening whatitis called “Teservoir effee 六