Question

Emily

請問句末的reservoir effect是儲庫效應嗎？（Fig1）
是的話，請幫我繼續解答🙏
有一個含萃取物凝膠，塗抹在皮膚上，滲透係數Kp 較低，但是滯留時間Lag time很長，所以文章解釋為reservoir effect儲庫效應，我看了一下參考文獻(fig2)，但是舉的例子是藥物類的，但如果是保養品類呢？
存在角質層有什麼功用呢？

The HPLC analysis ofthe last samples colleceted in the permeation assays allowed to
caleulate the percentage ofbioactive compounds that permeated through the biologieal
barrier after 24 hours as well as their permeation fluxes, expressed as hg em? hi (Table
3). Asp-eoumarie acid and caffeic acid are slightly lipophilic, iis possible that, even 放
they did not manage to pass the s/rgjo corjezo, they were trapped in the human

membrane, happening whatitis called “Teservoir effee 六

The low amount of permeation (less than 4.0% after 48 h for PT and TC emulsions) can be
explained by the reservoir effectlargely described forthe SC, which can have advantages for
clinicalapplications oftopicalsteroids.

The results obtained confirm the reservoir effecttheory for SC, which can be positive forthe
treatment of skin diseases avoiding the adverse effects caused by the action ofcorticoids on
fibroblasts receptors on dermlis and minimize the systemic effects,

reservoir effect sc 角質層 皮膚