Oncogenic Stimulation
(E1A, c-Myc,E2F-1, Ras)
DNA Damage ,UV
Hypoxia
Hypoglycemia
BRCA1
(ATM, DNA-PK. ATR)
P19ARF
HIF1a
p53
p53
Degraded
acetylat ion
Stable
dephosphorylation
mdm2 is an ubiquitin ligase
targeting P53 to proteolytic
degradation
p53
Stable and Active
Transactivation of target genes
PAG608
IGF-BP3
PIG3
KILLER/DR5
P21(WAF1) GADD45 14-3-36
BAX FAS/APO1
CKI
Repair
Apoptosis
00
Eom2